Blanton (2-0) struck out seven and worked into the seventh inning before being lifted after allowing a leadoff double.
Kelvin Herrera, Wade Davis and Greg Holland all pitched one inning of relief. Holland earned his 14th save in 15 opportunities.
Felix Hernandez (10-4) took the loss after allowing four runs, nine hits and a walk in 6 2/3 innings. He struck out five.
Escobar had three singles, drove in a run and scored a run. Mike Moustakas had two hits including an RBI double.