Paxton (3-2) won his third straight start, allowing two runs and four hits in six innings. It was his first road win since last Sept. 2 at Oakland. He’d gone 0-3 with a 5.30 ERA in his previous six outings away from home.
Paxton came in riding a 20-inning scoreless streak but couldn’t make it last beyond the first three batters. Josh Donaldson doubled, went to third on a wild pitch and scored on Edwin Encarnacion’s sacrifice fly.
Tom Wilhelmsen pitched the seventh, Carson Smith worked the eighth and Fernando Rodney finished for his 12th save.
The slumping Blue Jays lost for the 11th time in 14 games and fell to 2-10 in one-run decisions. They’ve lost sixth straight one-run games.
Mark Buehrle (5-4) gave up three runs and five hits in 7 1-3 innings.
Blue Jays pitchers have allowed at least one home run in each of the past nine games, giving up 17 in that span.
Seager tied it in the second with a one-out homer into the second deck in right.
The Mariners took advantage of suspect outfield defense to score two more in the third. Chris Taylor doubled over the head of Chirs Colabello in right, Rickie Weeks walked and Willie Bloomquist hit a two-run double beyond the reach of Danny Valencia in left.
Colabello cut the deficit to one with a two-out homer to left in the fourth.
Blue Jays: SS Ryan Goins fell down in pain as he broke out of the batter’s box on a grounder in the fifth. He received attention from the trainer before hobbling off the field but remained in the game.
Mariners: RHP Taijuan Walker (1-4, 7.47) is winless in his past four outings and 1-3 with a 10.71 ERA in five road starts. Walker lost 1-0 in his only career start against Toronto last Sept. 24 despite allowing one run in eight innings.
Blue Jays: RHP Aaron Sanchez (3-4, 4.17) has lost his past two starts. He pitched a career-high 7 1-3 innings against the Angels on May 19, giving up three runs on six hits.